SAV1 and STK4

Number of citations of the paper that reports this interaction (PubMedID 16930133)
85

Data Source:
HPRD (in vitro, in vivo)

		SAV1	STK4
Description		salvador family WW domain containing protein 1	serine/threonine kinase 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Population Maintenance	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Regulation Of Mitotic Cell Cycle Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Protein Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Neuron Projection Morphogenesis Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)	Bipolar disorder ( 31043756)
Interacting Genes		5 interacting genes: EP300 NEDD4 RASSF1 STK3 STK4	21 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX H2BC21 IL2RG KEAP1 LATS1 LATS2 MBP NEDD4 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53
Entrez ID		60485	6789
HPRD ID		06229	05395
Ensembl ID		ENSG00000151748	ENSG00000101109
Uniprot IDs		B3KTQ1 Q9H4B6	Q13043
PDB IDs		6AO5	2JO8 3COM 4NR2 4OH8 5TWG 5TWH
Enriched GO Terms of Interacting Partners?
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