RNF4 and UBE2D3

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (pull down, two hybrid, pull down, pull down)

		RNF4	UBE2D3
Description		ring finger protein 4	ubiquitin conjugating enzyme E2 D3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Ubiquitin Ligase Complex Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination MyD88-independent Toll-like Receptor Signaling Pathway DNA Repair Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Targeting To Peroxisome Apoptotic Process Protein Ubiquitination BMP Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Cadmium Ion Cellular Response To Mercury Ion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653)
Interacting Genes		39 interacting genes: AR ATXN1 ESR1 GSC2 H3C14 HMGA1 HNF4A IKBKG PATZ1 PGR SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TERF2 TRAIP TRIM28 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UEVLD	211 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CSNK2A1 CUL4B DBN1 DCUN1D1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 ERGIC3 ESR1 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO7 FBXW11 FBXW8 FOCAD FZR1 H2AC4 H3C1 HDAC6 HECTD1 HECW1 HECW2 HERC1 HERC2 HUWE1 IKBKG ITCH KAT2B KDM1B LRSAM1 MAEA MAP3K1 MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PER2 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF216 RNF220 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SHOC2 SIAH1 SIAH2 SMURF1 SMURF2 SOX2 SQSTM1 ST7 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TP73 TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4
Entrez ID		6047	7323
HPRD ID		04167	04269
Ensembl ID		ENSG00000063978	ENSG00000109332
Uniprot IDs		P78317	A0A024RDH2 D6RAH7 P61077
PDB IDs		2EA6 2XEU 4PPE	1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0
Enriched GO Terms of Interacting Partners?
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