RIT2 and RGL1

Number of citations of the paper that reports this interaction (PubMedID 10545207)
24

Data Source:
HPRD (in vitro)

		RIT2	RGL1
Description		Ras like without CAAX 2	ral guanine nucleotide dissociation stimulator like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Cellular_component Cytosol
	Molecular Function	Chromatin Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Protein Binding Ral Guanyl-nucleotide Exchange Factor Activity
	Biological Process	MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Small GTPase Mediated Signal Transduction Regulation Of Lipid Metabolic Process
Pathways		Signalling to p38 via RIT and RIN	PPARA activates gene expression
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adverse response to drug ( 30420678) Alcohol consumption (drinks per week) ( 30679032) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 27182965 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)	Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 29403010) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		12 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2	4 interacting genes: APP HRAS RIT1 RIT2
Entrez ID		6014	23179
HPRD ID		15253	12032
Ensembl ID		ENSG00000152214	ENSG00000143344
Uniprot IDs		Q99578	B7Z2W5 B7Z915 B7ZB61 Q9NZL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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