RFC5 and CHTF18

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RFC5	CHTF18
Description		replication factor C subunit 5	chromosome transmission fidelity factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Nucleoplasm Cytosol Membrane Ctf18 RFC-like Complex
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity Enzyme Binding	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Cell Cycle DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Neurociticism ( 29500382) Obesity-related traits ( 23251661)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)
Interacting Genes		15 interacting genes: BRD4 CHTF18 COPS6 DAPK1 EEF1A1 LRIF1 MED31 NAB2 PCNA RBM48 RFC2 RFC4 TRIM38 UNC119 XIAP	5 interacting genes: CRK PCNA RFC4 RFC5 STAT3
Entrez ID		5985	63922
HPRD ID		02677	13059
Ensembl ID		ENSG00000111445	ENSG00000127586
Uniprot IDs		P40937 Q59GW7	Q8WVB6
PDB IDs		1LFS
Enriched GO Terms of Interacting Partners?
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