BCL2A1 and BBC3

Number of citations of the paper that reports this interaction (PubMedID 15694340)
667

Data Source:
HPRD (in vitro)

		BCL2A1	BBC3
Description		BCL2 related protein A1	BCL2 binding component 3
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane	Mitochondrion Lysosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding	Protein Binding ATPase Binding
	Biological Process	Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cerebral Cortex Development Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Eosinophil counts ( 29403010 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	Monocyte count ( 27863252)
Interacting Genes		17 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK FAM9B GRB2 GSK3B HRK NR4A1 PMAIP1 SLC9A3R1	6 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1
Entrez ID		597	27113
HPRD ID		03034	16165
Ensembl ID		ENSG00000140379	ENSG00000105327
Uniprot IDs		Q16548	Q96PG8 Q9BXH1
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8
Enriched GO Terms of Interacting Partners?
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