CCND1 and KLK7

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		CCND1	KLK7
Description		cyclin D1	kallikrein related peptidase 7
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Bicellular Tight Junction Transcriptional Repressor Complex Nuclear Membrane	Extracellular Region Extracellular Space Secretory Granule Epidermal Lamellar Body
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding Proline-rich Region Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Response To Leptin Mitotic Cell Cycle Phase Transition Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Cell Division Response To Corticosterone Response To Calcium Ion Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Degradation of the extracellular matrix
Drugs		Arsenic trioxide	L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Diseases		Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
GWAS		Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 29059683 20453838) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 26237428) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 30429480) Offspring birth weight ( 31043758) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30297969 30718926)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		70 interacting genes: AKAP8 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDH13 CDK4 CDK6 CDKN1A CDKN1B CRYAB CTNNB1 CUL2 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1	10 interacting genes: APP BAG4 CCND1 CDSN CHEK2 PTPN1 PTPRJ STK11 TGFB1 WT1
Entrez ID		595	5650
HPRD ID		01346	05115
Ensembl ID		ENSG00000110092	ENSG00000169035
Uniprot IDs		P24385 Q6FI00	A0A024R4H6 B4DHX9 P49862
PDB IDs		2W96 2W99 2W9F 2W9Z 5VZU	2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK
Enriched GO Terms of Interacting Partners?
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