RAD51D and XRCC2

Number of citations of the paper that reports this interaction (PubMedID 10749867)
68

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		RAD51D	XRCC2
Description		RAD51 paralog D	X-ray repair cross complementing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Gamma-tubulin Binding	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Reciprocal Meiotic Recombination Interstrand Cross-link Repair Strand Invasion Regulation Of Cell Cycle	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Diabetic kidney disease ( 26305897) Mean platelet volume ( 27863252) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		22 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CEP57L1 EFHC2 IHO1 IKZF1 IKZF3 KIFC3 KRT15 LNX1 LZTS2 PRDM14 RAD51B RAD51C RHOU RNF138 SWSAP1 XRCC2 XRCC3 ZSWIM7	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		5892	7516
HPRD ID		04261	02656
Ensembl ID		ENSG00000185379	ENSG00000196584
Uniprot IDs		O75771	A0A384MEK2 O43543
PDB IDs		2KZ3
Enriched GO Terms of Interacting Partners?
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