BCAT1 and SMAD5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
HPRD (two hybrid)

		BCAT1	SMAD5
Description		branched chain amino acid transaminase 1	SMAD family member 5
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Protein-containing Complex SMAD Protein Complex
	Molecular Function	Branched-chain-amino-acid Transaminase Activity Identical Protein Binding L-leucine Transaminase Activity L-valine Transaminase Activity L-isoleucine Transaminase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Branched-chain Amino Acid Biosynthetic Process Branched-chain Amino Acid Catabolic Process Leucine Biosynthetic Process Valine Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Mullerian Duct Regression Osteoblast Fate Commitment Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Embryonic Pattern Specification Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Cardiac Muscle Contraction Bone Development SMAD Protein Signal Transduction Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Branched-chain amino acid catabolism	Signaling by BMP
Drugs		Pyridoxal Phosphate Glutamic Acid L-Leucine L-Valine L-Isoleucine N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
Diseases
GWAS		Adventurousness ( 30643258) Atrial fibrillation ( 29892015) Breast cancer ( 31757997) Calcium levels ( 25972035) Erythrocyte cadmium concentration ( 27005419) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) PR interval ( 30679814) Pulse pressure ( 30224653) Response to statin therapy ( 20339536) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Uterine fibroid size (maximum volume) ( 30196971)	Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Sleep duration (short sleep) ( 30846698)
Interacting Genes		3 interacting genes: KDM1A PRMT6 SMAD5	44 interacting genes: ACVR1 ANKRD13A BCAT1 BMP6 CHMP3 COPS5 CXXC5 EP300 FLNA GDF6 HBG2 HGS HOXA13 HOXD13 MBD1 MEN1 MTMR10 NEDD4 PLEKHO1 PNKP PPIL4 PSMD11 PTPN12 RBM4 RYR2 SF3B1 SF3B3 SFPQ SMAD1 SMAD4 SMURF1 SMURF2 SNRNP70 SNRPA SOX5 SOX7 SUV39H1 SUV39H2 TOB1 U2AF2 UBA1 WWP1 ZEB2 ZNF8
Entrez ID		586	4090
HPRD ID		00216	04381
Ensembl ID		ENSG00000060982	ENSG00000113658
Uniprot IDs		A0A024RAV0 P54687	Q68DB7 Q99717
PDB IDs		2ABJ 2COG 2COI 2COJ	6FZS 6TCE
Enriched GO Terms of Interacting Partners?
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