PTPRR and ROR1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PTPRR	ROR1
Description		protein tyrosine phosphatase receptor type R	receptor tyrosine kinase like orphan receptor 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Integral Component Of Membrane Cell Junction Perinuclear Region Of Cytoplasm	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Axon Terminus
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Inner Ear Development Anatomical Structure Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)	Blood protein levels ( 30072576 29875488) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817)
Interacting Genes		24 interacting genes: AATK EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK TEK	13 interacting genes: APP DUPD1 DUSP14 DUSP18 DUSP19 DUSP21 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX
Entrez ID		5801	4919
HPRD ID		04169	03821
Ensembl ID		ENSG00000153233	ENSG00000185483
Uniprot IDs		Q15256 Q7Z2V8	Q01973
PDB IDs		2A8B	5Z55 6BA5 6BAN
Enriched GO Terms of Interacting Partners?
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