PTPRF and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 10777529)
16

Data Source:
HPRD (in vivo, two hybrid)

		PTPRF	PTPRA
Description		protein tyrosine phosphatase receptor type F	protein tyrosine phosphatase receptor type A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Exosome Schaffer Collateral - CA1 Synapse Integral Component Of Synaptic Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	MAPK Cascade Protein Dephosphorylation Axon Guidance Insulin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Modulation Of Chemical Synaptic Transmission
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)	Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		55 interacting genes: ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B ZNF512B	17 interacting genes: BCAR1 CALM1 EGFR FYN GABARAPL2 GRB2 HSPB1 KCNA2 LINC00839 MBP POFUT1 PRKCD PTPRD PTPRF PTPRM PTPRS SRC
Entrez ID		5792	5786
HPRD ID		01552	01476
Ensembl ID		ENSG00000142949	ENSG00000132670
Uniprot IDs		G1UI20 P10586	P18433
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U
Enriched GO Terms of Interacting Partners?
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