HAMP and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
7

Data Source:
BioGRID (two hybrid)

		HAMP	VKORC1
Description		hepcidin antimicrobial peptide	vitamin K epoxide reductase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Intercalated Disc Apical Cortex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Hormone Activity	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Signal Transduction Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Response To Ethanol Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Oxidation-reduction Process Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Irritable bowel syndrome ( 29673008) Red cell distribution width ( 28957414)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		5 interacting genes: CKAP4 EXOSC5 GLP1R SLC40A1 VKORC1	83 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CREB3 CXADR DCTPP1 DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		57817	79001
HPRD ID		05925	10540
Ensembl ID		ENSG00000105697	ENSG00000167397
Uniprot IDs		P81172	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1M4E 1M4F 2KEF 3H0T 4QAE
Enriched GO Terms of Interacting Partners?
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