CCDC146 and RNF40

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCDC146	RNF40
Description		coiled-coil domain containing 146	ring finger protein 40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centriole	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Membrane Extrinsic Component Of Membrane HULC Complex Neuron Projection Axon Terminus
	Molecular Function	Protein Binding	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Syntaxin-1 Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process		Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Protein Ubiquitination Histone H2B Ubiquitination Response To Peptide Hormone Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Histone H2B Ubiquitination
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Body mass index ( 28892062) Response to amphetamines ( 22952603)	Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		33 interacting genes: CBY2 CCDC136 CCNDBP1 CEP170P1 CEP44 DTNBP1 GOLGA2 KRT18 KRT19 KRT38 KRT40 MAGEA11 MAGEA6 MED4 MTUS2 NECAB2 NINL NUP62 PDE4DIP PNMA1 PSMC6 RINT1 RNF40 RPGRIP1 TFIP11 TNR TPM3 TRAF1 TRIM23 TRIM54 TSC22D4 USHBP1 VPS52	22 interacting genes: AMOTL2 ATM CCDC146 CDC73 EEF1D ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 RB1 RNF20 SFR1 TRIM51 UBE2A UBE2B UBE2D2 UBE2E1 UBE2I UBE2L6 ZNF451
Entrez ID		57639	9810
HPRD ID		11150	07411
Ensembl ID		ENSG00000135205	ENSG00000103549
Uniprot IDs		Q8IYE0 Q96MS1	A8K6K1 O75150
PDB IDs
Enriched GO Terms of Interacting Partners?
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