ADGRB2 and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 10964907)
21

Data Source:
HPRD (two hybrid)

		ADGRB2	SHANK1
Description		adhesion G protein-coupled receptor B2	SH3 and multiple ankyrin repeat domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Cell Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Protein Binding Protein C-terminus Binding SH3 Domain Binding Receptor Signaling Complex Scaffold Activity GKAP/Homer Scaffold Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Angiogenesis Calcineurin-NFAT Signaling Cascade Positive Regulation Of Synapse Assembly	Cytoskeletal Anchoring At Plasma Membrane Synapse Assembly Behavior Long-term Memory Associative Learning Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Brain Morphogenesis Neuromuscular Process Controlling Balance Determination Of Affect Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Righting Reflex Synapse Maturation Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Intraocular pressure ( 29617998 29785010) Smoking status (ever vs never smokers) ( 30643258)	Clozapine-induced cytotoxicity ( 25656473)
Interacting Genes		8 interacting genes: ARHGAP1 GABPB1 HDHD2 LRP2BP SHANK1 SHANK2 SNTA1 STARD13	18 interacting genes: ABCA1 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 HOMER1 RPS6KA2 RPS6KA3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 USP8
Entrez ID		576	50944
HPRD ID		04063	05413
Ensembl ID		ENSG00000121753	ENSG00000161681
Uniprot IDs		O60241	H9KV90 Q9Y566
PDB IDs			6CPI
Enriched GO Terms of Interacting Partners?
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