NUFIP2 and ICOS

Number of citations of the paper that reports this interaction (PubMedID 29352114)
9

Data Source:
BioGRID (unspecified method)

		NUFIP2	ICOS
Description		nuclear FMR1 interacting protein 2	inducible T cell costimulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Body Polysomal Ribosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	RNA Binding Protein Binding	Protein Binding
	Biological Process		T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion
Pathways
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Depression ( 29700475) Headache ( 29397368) Heel bone mineral density ( 30598549)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		25 interacting genes: CRK EFEMP2 FMR1 ICOS KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LGALS13 PCSK5 RGS17 STAT3 TNFRSF4 TRAF1 YWHAG	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		57532	29851
HPRD ID		11764	09196
Ensembl ID		ENSG00000108256	ENSG00000163600
Uniprot IDs		Q7Z417	Q53QY6 Q9Y6W8
PDB IDs
Enriched GO Terms of Interacting Partners?
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