PTK6 and FCHO1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PTK6	FCHO1
Description		protein tyrosine kinase 6	FCH and mu domain containing endocytic adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding	Protein Binding Cytoskeletal Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid	Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Vandetanib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)	Coronary artery disease ( 29212778)
Interacting Genes		16 interacting genes: APP CCDC33 DOK1 EFHC2 EGFR ERBB3 EXOC5 FCHO1 FGFR1 HIF1A KHDRBS1 KHDRBS2 LINC01139 REL STAP2 WASL	17 interacting genes: ACVR1 APP DAB2 DNAJC5 EPS15 EPS15L1 EXOSC5 GDF15 ITSN1 LGALS14 NCK1 PICALM PTK6 SMURF1 SRPK2 ZBTB16 ZNF688
Entrez ID		5753	23149
HPRD ID		03594	16887
Ensembl ID		ENSG00000101213	ENSG00000130475
Uniprot IDs		Q13882	A0A0C3SFZ9 B7ZAZ3 O14526
PDB IDs		1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4
Enriched GO Terms of Interacting Partners?
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