PTHLH and IL6

Number of citations of the paper that reports this interaction (PubMedID 12000745)
4

Data Source:
HPRD (in vitro)

		PTHLH	IL6
Description		parathyroid hormone like hormone	interleukin 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Extracellular Region Extracellular Space Cell Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex
	Molecular Function	Hormone Activity Protein Binding Peptide Hormone Receptor Binding	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Skeletal System Development Osteoblast Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Bone Mineralization Regulation Of Chondrocyte Differentiation Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Chondrocyte Development	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Humoral Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-17 Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Apoptotic DNA Fragmentation Regulation Of Microglial Cell Activation Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response
Drugs			Ginseng YSIL6 VX-702 CRx-139 Andrographolide Tapinarof Siltuximab Binimetinib Dilmapimod
Diseases			Graft-versus-host disease
GWAS		Asthma and hay fever ( 24388013) Blood protein levels ( 30072576 29875488) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 23535729 23535733 27117709 31757997) Breast cancer (estrogen-receptor negative) ( 27117709) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast size ( 22747683 27182965) Height ( 31562340) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis (hip) ( 30664745)	Asthma ( 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30224653 30578418) Takayasu arteritis ( 25604533)
Interacting Genes		7 interacting genes: ARRB1 CDK2 IL6 KLK3 KPNB1 MTDH PTH1R	5 interacting genes: IL6R IL6ST PTHLH SH3GL2 ZBTB16
Entrez ID		5744	3569
HPRD ID		01348	00970
Ensembl ID		ENSG00000087494	ENSG00000136244
Uniprot IDs		A0A024RB29 P12272 Q53XY9	B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2
PDB IDs		1BZG 1ET3 1M5N 3FFD 3H3G	1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC
Enriched GO Terms of Interacting Partners?
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