VANGL2 and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 15195140)
33

Data Source:
HPRD (in vitro, in vivo)

		VANGL2	MAGI3
Description		VANGL planar cell polarity protein 2	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Cell Pole	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction
	Molecular Function	Protein Binding	Guanylate Kinase Activity Protein Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Heart Looping Membranous Septum Morphogenesis Muscular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Axis Elongation Rho Protein Signal Transduction Anterior/posterior Pattern Specification Heparan Sulfate Proteoglycan Biosynthetic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Wnt Signaling Pathway Glomerulus Development Regulation Of Actin Cytoskeleton Organization Somatic Stem Cell Population Maintenance Cell Migration Involved In Kidney Development Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Wound Healing Positive Regulation Of JUN Kinase Activity Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Somatic Stem Cell Division Establishment Of Body Hair Planar Orientation Digestive Tract Morphogenesis Convergent Extension Involved In Axis Elongation Inner Ear Receptor Cell Stereocilium Organization Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Kidney Morphogenesis Planar Cell Polarity Pathway Involved In Heart Morphogenesis Cochlea Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Neural Tube Closure Planar Cell Polarity Pathway Involved In Axon Guidance Non-motile Cilium Assembly	Apoptotic Process Signal Transduction Viral Process Intracellular Signal Transduction GMP Metabolic Process Regulation Of JNK Cascade GDP Metabolic Process
Pathways		PCP/CE pathway Asymmetric localization of PCP proteins
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Multiple sclerosis ( 31604244 24076602) Systemic lupus erythematosus ( 28714469)	Alopecia areata ( 25608926) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Gut microbiota (bacterial taxa) ( 27694959) Obesity-related traits ( 23251661) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		5 interacting genes: AP1M1 ARFRP1 DVL1 MAGI3 SQSTM1	16 interacting genes: ADGRB1 ADRB1 CRHR1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB RPS6KA1 TGFA TNK2 VANGL2
Entrez ID		57216	260425
HPRD ID		02758	11290
Ensembl ID		ENSG00000162738	ENSG00000081026
Uniprot IDs		A8K4L6 Q9ULK5	Q5TCQ9
PDB IDs			3SOE
Enriched GO Terms of Interacting Partners?
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