ADAMTSL3 and KRTAP2-4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ADAMTSL3	KRTAP2-4
Description		ADAMTS like 3	keratin associated protein 2-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Intracellular Membrane-bounded Organelle	Cytosol Keratin Filament
	Molecular Function	Protein Binding Peptidase Activity	Protein Binding
	Biological Process	Proteolysis	Keratinization
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Keratinization Keratinization
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 25673412) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 26785701 25673412 28448500)
Interacting Genes		6 interacting genes: KRT40 KRTAP10-3 KRTAP10-8 KRTAP2-4 MDFI NOTCH2NLA	11 interacting genes: ADAMTSL3 CBX2 CNNM3 KRTAP10-1 KRTAP10-5 PTPMT1 RPS28 SDC3 SHFL TMEM190 ZNF587
Entrez ID		57188	85294
HPRD ID		12426	13936
Ensembl ID		ENSG00000156218	ENSG00000213417
Uniprot IDs		P82987	P0C7H8 Q9BYR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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