RPGRIP1 and RNF6

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		RPGRIP1	RNF6
Description		RPGR interacting protein 1	ring finger protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Axoneme Photoreceptor Connecting Cilium	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Visual Perception Eye Photoreceptor Cell Development Response To Stimulus Retina Development In Camera-type Eye Neural Precursor Cell Proliferation	Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Height ( 31562340) Superior temporal sulcus banks volume ( 31530798)	Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 30297969 30718926 28869590) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	36 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STX11 TADA2A TCF4 TFIP11 TNS2 TRIM23 TRIM27 TRIM37 TSGA10 UBE2D1 UBE2H
Entrez ID		57096	6049
HPRD ID		05673	05027
Ensembl ID		ENSG00000092200	ENSG00000127870
Uniprot IDs		Q96KN7	A0A024RDP2 A0A0S2Z4G9 Q9Y252
PDB IDs		4QAM
Enriched GO Terms of Interacting Partners?
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