PSAP and TOMM70

		PSAP	TOMM70
Description		prosaposin	translocase of outer mitochondrial membrane 70
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Aggresome Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protease Binding Beta-galactosidase Activity Protein Binding Phospholipid Binding Enzyme Activator Activity Lipid Binding Lipid Antigen Binding Protein Homodimerization Activity Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	NK T Cell Differentiation Platelet Degranulation Corneocyte Development Glucosylceramide Metabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Lipid Transport Intracellular Protein Transport Lysosomal Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Sound Protein Secretion Gene Expression Regulation Of Autophagy Regulation Of Lipid Metabolic Process Antigen Processing And Presentation Cerebellar Purkinje Cell Differentiation Myelination Neutrophil Degranulation Positive Regulation Of MAPK Cascade Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity Micturition Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Inclusion Body Assembly Cellular Response To Organic Substance Cochlea Development Walking Behavior Negative Regulation Of Hydrogen Peroxide-induced Cell Death Cornified Envelope Assembly Lysosomal Protein Catabolic Process Ganglioside GM1 Transport To Membrane	Protein Targeting To Mitochondrion Macroautophagy Protein Transmembrane Transport
Pathways		Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation	Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases		Krabbe disease; Globoid cell leukodystrophy Metachromatic leukodystrophy (MLD) Gaucher disease
GWAS		Asthma (childhood onset) ( 23829686) Blood protein levels ( 30072576) Seasonality and depression ( 30217971)
Interacting Genes		18 interacting genes: BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PRAG1 SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1	15 interacting genes: CTNNA2 DCBLD2 FOXC1 HSP90AA1 HSPA1A HSPB1 IRF3 KIF2C NIT2 OR5K4 PRKN PSAP TBC1D23 TFG TMEM45A
Entrez ID		5660	9868
HPRD ID		01460	16194
Ensembl ID		ENSG00000197746	ENSG00000154174
Uniprot IDs		A0A024QZQ2 P07602	O94826
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O
Enriched GO Terms of Interacting Partners?
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