RNF20 and KIF11

Number of citations of the paper that reports this interaction (PubMedID 27557628)
13

Data Source:
BioGRID (enzymatic study)

		RNF20	KIF11
Description		ring finger protein 20	kinesin family member 11
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex	Spindle Pole Nucleus Spindle Cytosol Kinesin Complex Microtubule Spindle Microtubule Membrane Protein-containing Complex Mitotic Spindle
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Metal Ion Binding	Microtubule Motor Activity ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Protein Kinase Binding
	Biological Process	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Histone Monoubiquitination Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of Histone Methylation Histone H2B Ubiquitination Positive Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Polyadenylation Positive Regulation Of Histone H2B Ubiquitination	Mitotic Cell Cycle Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Mitotic Centrosome Separation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Centrosome Separation Cell Division Mitotic Spindle Assembly
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS			Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29785010 30054594) Type 2 diabetes ( 21490949 31118516)
Interacting Genes		30 interacting genes: AMOTL2 ATM BAG4 FBXO7 FGFR4 H2AC18 H2AC20 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 PA2G4 PAF1 RB1CC1 RNF40 SMURF2 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17	9 interacting genes: AURKA CDK1 DCTN1 ERCC1 ERCC4 PPARG RNF20 RNF40 SRPK2
Entrez ID		56254	3832
HPRD ID		07410	01023
Ensembl ID		ENSG00000155827	ENSG00000138160
Uniprot IDs		Q5VTR2	P52732
PDB IDs		5TRB	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY
Enriched GO Terms of Interacting Partners?
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