THAP12 and MAPKAPK3

Number of citations of the paper that reports this interaction (PubMedID 20484669)
10

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		THAP12	MAPKAPK3
Description		THAP domain containing 12	MAPK activated protein kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Cell Proliferation	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Intracellular Signal Transduction Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways			p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation
Drugs			2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)	Blood protein levels ( 28240269) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331)
Interacting Genes		8 interacting genes: DDX58 DNAJC3 EIF2AK2 EIF2S1 MAPKAPK3 STK4 TACC1 TP53	21 interacting genes: APP ATF1 BECN1 CHMP2A COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK13 MAPK14 NEDD4 NEDD4L RAB2A RCSD1 SMS SRPK2 SUMO3 TCF3 THAP12
Entrez ID		5612	7867
HPRD ID		09567	03678
Ensembl ID		ENSG00000137492	ENSG00000114738
Uniprot IDs		A0A140VJQ7 O43422	A0A024R2W7 Q16644
PDB IDs			3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?
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