MAP2K3 and NFIC

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP2K3	NFIC
Description		mitogen-activated protein kinase kinase 3	nuclear factor I C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity
	Biological Process	Activation Of MAPK Activity Inflammatory Response Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Body mass index ( 26426971 28892062)	Alzheimer's disease (APOE e4 interaction) ( 28183528) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Nevus count or cutaneous melanoma ( 30429480) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196)
Interacting Genes		55 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	25 interacting genes: CBLC CREBBP DACH1 EPHA2 ERGIC1 FBXO7 GLIS1 GLIS2 GLRX LATS2 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 RELA RFX1 SOX3 TEAD2 TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7
Entrez ID		5606	4782
HPRD ID		03816	09009
Ensembl ID		ENSG00000034152	ENSG00000141905
Uniprot IDs		P46734 Q6FI23	B7Z4T6 P08651
PDB IDs
Enriched GO Terms of Interacting Partners?
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