MAPK11 and DUSP16

Number of citations of the paper that reports this interaction (PubMedID 11359773)
43

Data Source:
HPRD (in vitro)

		MAPK11	DUSP16
Description		mitogen-activated protein kinase 11	dual specificity phosphatase 16
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Activation Of MAPK Activity Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Interleukin-12 Secretion	Inactivation Of MAPK Activity Dephosphorylation Peptidyl-tyrosine Dephosphorylation MAPK Export From Nucleus MAPK Phosphatase Export From Nucleus, Leptomycin B Sensitive
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy
Drugs		KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181)	Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	9 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9
Entrez ID		5600	80824
HPRD ID		04208	09525
Ensembl ID		ENSG00000185386	ENSG00000111266
Uniprot IDs		Q15759	A0A024RAR2 Q9BY84
PDB IDs		3GC8 3GC9 3GP0	2VSW 3TG3 4YR8
Enriched GO Terms of Interacting Partners?
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