PSENEN and THBD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PSENEN	THBD
Description		presenilin enhancer, gamma-secretase subunit	thrombomodulin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex	Extracellular Space Vacuolar Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apicolateral Plasma Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process	Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation	Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs		E-2012	Drotrecogin alfa Ibuprofen Dexibuprofen
Diseases		Acne inversa; Hidradenitis supprativa	Inherited thrombophilia
GWAS			Blood protein levels in cardiovascular risk ( 28369058) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		7 interacting genes: APH1A CREB3 NCSTN PSEN1 PSEN2 THBD TMED10	6 interacting genes: F2 LMNA PF4 PROC PSENEN SERPINA5
Entrez ID		55851	7056
HPRD ID		06362	01764
Ensembl ID		ENSG00000205155	ENSG00000178726
Uniprot IDs		Q9NZ42	P07204
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3
Enriched GO Terms of Interacting Partners?
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