DCP1A and PNRC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		DCP1A	PNRC2
Description		decapping mRNA 1A	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Enzyme Regulator Activity Identical Protein Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Catalytic Activity Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) Spontaneous preterm birth (preterm delivery) ( 25599974)	Obesity-related traits ( 23251661)
Interacting Genes		15 interacting genes: AGO1 AGO2 DCP2 EDC3 FHL2 LSM8 MAPK3 NSMAF PAXIP1 PNRC2 RITA1 SMAD4 TTF2 UPF1 YWHAG	21 interacting genes: APP AR DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		55802	55629
HPRD ID		06113	17871
Ensembl ID		ENSG00000272886	ENSG00000189266
Uniprot IDs		Q9NPI6	Q9NPJ4
PDB IDs		2WX3 4B6H	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?
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