PRKAR1A and PATZ1

Number of citations of the paper that reports this interaction (PubMedID 20026299)
8

Data Source:
BioGRID (two hybrid, pull down)

		PRKAR1A	PATZ1
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	POZ/BTB and AT hook containing zinc finger 1
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Ciliary Base Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Metal Ion Binding
	Biological Process	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Spermatogenesis Male Gonad Development T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs		Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate Cyclic Guanosine Monophosphate Cyclic Adenosine Monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)	Height ( 31562340) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WDCP WNK1 YWHAZ ZBED1	7 interacting genes: BACH1 BACH2 CLK1 MITF PRKAR1A RBPMS RNF4
Entrez ID		5573	23598
HPRD ID		01786	05522
Ensembl ID		ENSG00000108946	ENSG00000100105
Uniprot IDs		B2R5T5 P10644	A0A024R1F8 A0A024R1H7 A0A024R1M5 Q9HBE1
PDB IDs		5KJX 5KJY 5KJZ	2EPP 2EPQ 2EPR 2EPS 2YT9
Enriched GO Terms of Interacting Partners?
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