SYNJ2BP and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 30726710)
1

Data Source:
BioGRID (unspecified method)

		SYNJ2BP	RPS6KA1
Description		synaptojanin 2 binding protein	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Mitochondrion Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction Integral Component Of Mitochondrial Outer Membrane Neuromuscular Junction Neuron Projection Postsynaptic Density Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Targeting Rho Protein Signal Transduction Chemical Synaptic Transmission Regulation Of Notch Signaling Pathway Embryo Development Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Endocytosis Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Intracellular Distribution Of Mitochondria Negative Regulation Of ERK1 And ERK2 Cascade Receptor Localization To Synapse Cell-cell Adhesion Negative Regulation Of Sprouting Angiogenesis	Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Purvalanol A
Diseases
GWAS		Blood pressure ( 24954895) LDL cholesterol ( 30275531) Normal facial asymmetry (angle of surface orientation score) ( 30631343)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Glucose homeostasis traits ( 25524916) Mean corpuscular volume ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155)
Interacting Genes		13 interacting genes: ACTB ACVR2A ACVR2B APP LRP1 LRP2 LRP8 RALBP1 RPS6KA1 SMOC1 SYNJ2 UBQLN1 USHBP1	86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		55333	6195
HPRD ID		15455	03402
Ensembl ID		ENSG00000213463	ENSG00000117676
Uniprot IDs		A0A024R670 P57105	Q15418
PDB IDs		2ENO 2JIK 2JIN	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62
Enriched GO Terms of Interacting Partners?
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