THAP1 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		THAP1	LASP1
Description		THAP domain containing 1	LIM and SH3 protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body Intracellular Membrane-bounded Organelle	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding	SH3/SH2 Adaptor Activity Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Mitotic Cell Cycle	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		65 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BMS1P1 BYSL C1orf35 C7orf50 CHD2 CSNK2A1 DCAF8 DVL2 EEF1AKNMT FAM124A FAM133A FXR2 GOLGA7 GPATCH2L HNRNPLL KLF12 KRTAP10-7 LASP1 MORF4L1 MORF4L2 MRPL11 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PID1 POLR2L POLR2M PPIG PRKAA1 PRR20A QKI RALYL RBM10 RBM39 RIPPLY1 RP9P RPS25 SAP30BP SERF2 SLU7 STRBP TCEA2 TPM3 TRAF5 TRIM26 TTLL10 TXN2 U2AF2 WT1 YES1 ZCCHC10 ZNF385C ZNF408	40 interacting genes: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 COPS5 CRK DAZAP2 DNMT1 EHMT2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 RBPMS REL RHOXF2 SEPTIN3 SPRY2 STAT3 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 UHRF1 ZBTB9 ZC2HC1A ZYX
Entrez ID		55145	3927
HPRD ID		15496	04229
Ensembl ID		ENSG00000131931	ENSG00000002834
Uniprot IDs		Q9NVV9	A0A024R1S8 B4DIC4 Q14847
PDB IDs		2JTG 2KO0 2L1G	3I35
Enriched GO Terms of Interacting Partners?
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