FANCL and EIF4ENIF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FANCL	EIF4ENIF1
Description		FA complementation group L	eukaryotic translation initiation factor 4E nuclear import factor 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex	P-body Nucleus Cytoplasm Cytosol Membrane PML Body Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Proliferation	Protein Transport Negative Regulation Of Translation Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Nuclear Export
Pathways		Fanconi Anemia Pathway
Drugs
Diseases		Fanconi anemia
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Generalized epilepsy ( 30531953) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)	Age-related hearing impairment ( 24939585)
Interacting Genes		26 interacting genes: ACVR1 BMPR1B CHCHD3 CTBP1 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GGN GRN HES1 IHO1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W	21 interacting genes: ATXN1 CDK6 DDX6 DEF6 DTX2 EFHC1 EIF3E EIF4E EIF4E2 FANCL FDPS HNRNPF KRT19 LSM14A MGAT5B NIN OIP5 SMAD3 SPAG5 TTC19 TXLNA
Entrez ID		55120	56478
HPRD ID		06997	10456
Ensembl ID		ENSG00000115392	ENSG00000184708
Uniprot IDs		Q9NW38	A0A024R1K0 Q9NRA8
PDB IDs		3ZQS 4CCG	5ANR 6F9W
Enriched GO Terms of Interacting Partners?
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