RBFOX1 and CRX

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		RBFOX1	CRX
Description		RNA binding fox-1 homolog 1	cone-rod homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network	Nuclear Chromatin Nucleus
	Molecular Function	RNA Binding MRNA Binding Protein Binding Protein C-terminus Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Nuclear Hormone Receptor Binding Leucine Zipper Domain Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Transport	Regulation Of Transcription, DNA-templated Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Stimulus
Pathways		MECP2 regulates transcription factors
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 25085501) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Brain glucose metabolism (fluorodeoxyglucose uptake) ( 30596066) Brain volume in infants (cerebrospinal fluid) ( 28763065) Cerebellum white matter volume ( 31530798) Chronotype ( 30696823) Cocaine dependence ( 31212010) Cognitive decline rate in late mild cognitive impairment ( 26252872) Depression ( 29700475) Extraversion ( 27918536) Feeling worry ( 29500382) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 25027321) Hydrolysed wheat protein allergy ( 31301374) Hyperopia ( 25233373) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) Major depressive disorder ( 27479909 29728651) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 31628463) Myopia ( 27182965 25233373) Neurociticism ( 29500382) Neurofibrillary tangles ( 31497858) Neuroticism ( 29255261) Nickel levels ( 26025379) Obesity (extreme) ( 31852448) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) Pit-and-Fissure caries ( 24556642) Refractive astigmatism ( 30306274) Refractive error ( 23396134 23474815) Renal cell carcinoma ( 31231134) Rheumatoid arthritis ( 30423114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemising ( 31508503) Systolic blood pressure ( 30224653) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30130595) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		34 interacting genes: ALG13 ATN1 ATXN1 ATXN2 BHLHE40 C1orf94 CELF3 CRX DAB1 DAZAP2 DMRTB1 DVL2 FAM168A GCA HNRNPF HSFX1 HSFY1 KIFAP3 LZTS2 MAGED1 NOC2L NUMBL PCBP4 PRR20A PRRC2A PSMF1 QKI RBFOX2 RBM24 RBPMS RHOXF2 SNRPN STRBP TNIP1	54 interacting genes: ABI2 ACBD4 ATG12 ATM ATXN7 BANF1 BANP C1orf109 C9orf72 CA8 CCNC CREBBP CSNK1G2-AS1 DELE1 EIF5A EP300 GCM2 GUCD1 HGS IPO13 KAT2A KLHL32 LARP4 LONRF1 M1AP MDFI MLLT6 NIP7 NPAS2 NR2E3 NRL OSGIN1 PDC PICALM PID1 PPP1R16B PRKAB2 PRKN PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS ROR2 SFI1 SMAD3 SMUG1 SOX5 STK16 SZT2 TLE5 UBXN2B ZNF688
Entrez ID		54715	1406
HPRD ID		16091	03748
Ensembl ID		ENSG00000078328	ENSG00000105392
Uniprot IDs		B7Z1U7 Q59HD3 Q9NWB1 X5D7T5 X5DNY3 X5DP44	O43186
PDB IDs		2ERR 2N82 4ZKA
Enriched GO Terms of Interacting Partners?
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