CCHCR1 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCHCR1	NDC80
Description		coiled-coil alpha-helical rod protein 1	NDC80 kinetochore complex component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Centriole Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function		Protein Binding Identical Protein Binding
	Biological Process	Protein Export From Nucleus Multicellular Organism Development Cell Differentiation	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Feeling nervous ( 29500382) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Multiple myeloma ( 23955597) Nevirapine-induced rash ( 21810746) Night sleep phenotypes ( 27126917) Prostate cancer ( 21743467) Psoriasis ( 30921485) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 21738480)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		62 interacting genes: ABI2 ALAS1 AMOTL2 ATG5 BLOC1S6 C1orf94 CARD9 CBY2 CCDC102B CCDC136 CDR2 CEP55 CNN1 COG6 EFHC2 FSD2 GLRX3 GOLGA2 GRAP2 HAUS1 HSBP1 HSPB1 IKBKG KRT13 KRT15 KRT31 KRT40 MAD1L1 MED4 MIA2 MID2 MTUS2 NAB2 NDC80 NINL NME7 NUP62 NUTM1 PCM1 PIAS2 POLD2 POLR2C PRKCG RBM17 SAT1 SPAG5 SSX2IP STAR TADA2A TEKT1 TFIP11 TPM3 TRAF1 TRAF2 TRAF4 TRIM27 TSGA10 TXLNA TXLNB USHBP1 WASHC3 ZFYVE19	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		54535	10403
HPRD ID		05607	06277
Ensembl ID		ENSG00000204536	ENSG00000080986
Uniprot IDs		A0A1U9X7G6 Q2TB68 Q769H0 Q8TD31	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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