ADAMTSL4 and SPINK2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ADAMTSL4	SPINK2
Description		ADAMTS like 4	serine peptidase inhibitor Kazal type 2
Image		No pdb structure
GO Annotations	Cellular Component	Interstitial Matrix Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix	Acrosomal Vesicle Extracellular Region
	Molecular Function	Protease Binding Protein Binding Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Epithelial Cell Development Proteolysis Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process	Acrosome Assembly Spermatid Development Negative Regulation Of Serine-type Endopeptidase Activity
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Ectopia lentis
GWAS		Coronary artery disease ( 29212778) Migraine ( 27322543) Rhegmatogenous retinal detachment ( 23585552)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Blood protein levels ( 30072576 29875488) Migraine ( 27322543) Post bronchodilator FEV1/FVC ratio ( 26634245) Stroke ( 26089329) Systemic sclerosis ( 30247649)
Interacting Genes		110 interacting genes: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 CATSPER1 CCDC26 CFAP206 CHCHD2 CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL2 GNE GNMT GOLGA8EP HGF HNRNPLL HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LHX4 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 OTX1 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SHFL SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587	6 interacting genes: ADAMTSL4 CEP135 KRTAP10-3 KRTAP5-9 MAPK8IP2 NOTCH2NLA
Entrez ID		54507	6691
HPRD ID		18237	10422
Ensembl ID		ENSG00000143382	ENSG00000128040
Uniprot IDs		B7ZMJ3 Q6UY14 Q9UFG7	A0A024RD95 A0A087WTA9 D6RC51 D6RI10 P20155
PDB IDs			2JXD 6KBR
Enriched GO Terms of Interacting Partners?
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