POLR2L and POLR2G

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, pull down)

		POLR2L	POLR2G
Description		RNA polymerase II subunit L	RNA polymerase II subunit G
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	Single-stranded DNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase I Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of Type I Interferon Production Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Positive Regulation Of Viral Transcription Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Gene Silencing By MiRNA
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Pulse pressure ( 30578418)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: BANP CCDC85B CCN3 CHEK2 COIL EXOSC5 L3MBTL3 NFKBIB PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 ZBTB14	23 interacting genes: ATF7IP DDX54 EWSR1 FNDC4 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H POLR2K POLR2L PRKRA STK19 TAF15 TNNC1 TRIM14 VHL
Entrez ID		5441	5436
HPRD ID		01155	15995
Ensembl ID		ENSG00000177700	ENSG00000168002
Uniprot IDs		P62875	P62487
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L
Enriched GO Terms of Interacting Partners?
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