GNG2 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 15782186)
112

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GNG2	TBXA2R
Description		G protein subunit gamma 2	thromboxane A2 receptor
Image
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome	Acrosomal Vesicle Cell Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Cell Proliferation Platelet Activation Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs		Halothane	Ridogrel Seratrodast
Diseases
GWAS		Chronic obstructive pulmonary disease ( 25584925) Cognitive decline rate in late mild cognitive impairment ( 26252872) Craniofacial microsomia ( 26853712) High density lipoprotein cholesterol levels ( 29403010) Lung cancer (smoking interaction) ( 24658283) Non-melanoma skin cancer ( 23548203) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 31170924) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		15 interacting genes: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	22 interacting genes: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L YWHAZ
Entrez ID		54331	6915
HPRD ID		16234	01768
Ensembl ID		ENSG00000186469	ENSG00000006638
Uniprot IDs		P59768	P21731 Q05C92 Q0VAB0
PDB IDs		4KFM 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OS9 6OSA 6OT0	1LBN
Enriched GO Terms of Interacting Partners?
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