POLR2A and TRAK1

Number of citations of the paper that reports this interaction (PubMedID 12435728)
54

Data Source:
HPRD (in vivo)

		POLR2A	TRAK1
Description		RNA polymerase II subunit A	trafficking kinesin protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Nucleolus Cytoplasm	Cell Nucleus Cytoplasm Mitochondrion Early Endosome Cell Cortex Dendrite Cytoplasmic Vesicle Mitochondrial Membrane Axonal Growth Cone Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	RNA Polymerase II Activity DNA Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Promoter-specific Chromatin Binding	Signaling Receptor Binding Protein Binding Myosin Binding TPR Domain Binding GABA Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, RNA-templated Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway Viral Process RNA Metabolic Process Positive Regulation Of RNA Splicing Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Protein Targeting Anterograde Axonal Transport Protein Localization Endosome To Lysosome Transport Neurogenesis Vesicle Transport Along Microtubule Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Axonogenesis Anterograde Axonal Transport Of Mitochondrion
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression	Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Central corneal thickness ( 29760442) Heel bone mineral density ( 30598549) Myopia ( 27182965) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Body mass index ( 28552196) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		104 interacting genes: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CALCOCO1 CALCOCO2 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTDP1 CTDSP1 CTDSP2 DHX9 ELL ELOA ERCC5 ERCC6 ERG ESR1 FUS GRB2 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 GTF2H4 H1-2 HNRNPF HNRNPU HTATSF1 ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYH6 NEDD4 NONO NR0B2 NSD1 OTUD5 PCIF1 PHF8 PIN1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2L PPIG PPP1CA PQBP1 PRMT5 PRPF19 SAFB SKP2 SMN1 SMN2 SMURF1 SNAR-B2 SND1 SUB1 SUPT5H TAF10 TBP TCEA1 TCERG1 TRAK1 TRAM2 TTK U2AF2 UBE2L3 UPF1 VDR WAC XAB2 XRCC5 ZNF74	7 interacting genes: CDC5L CDK6 HGS OGT POLR2A SKIL TRAF3IP1
Entrez ID		5430	22906
HPRD ID		08916	09732
Ensembl ID		ENSG00000181222	ENSG00000182606
Uniprot IDs		A0A590UJN4 P24928	A0A087X0N0 B7Z218 B7ZAE5 Q9UPV9
PDB IDs		2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P 4JXT 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M3H 5M3J 6DRD 6F5P 6G0R 6O9L
Enriched GO Terms of Interacting Partners?
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