FXYD6 and C4BPA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FXYD6	C4BPA
Description		FXYD domain containing ion transport regulator 6	complement component 4 binding protein alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle
	Molecular Function	Molecular_function Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity	RNA Binding Protein Binding
	Biological Process	Biological_process Ion Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Complement Activation, Classical Pathway Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Ion homeostasis Ion transport by P-type ATPases	Regulation of Complement cascade
Drugs			Zinc Copper
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)	Blood protein levels ( 30072576 29875488) C4b binding protein levels ( 20212171) Mean platelet volume ( 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		15 interacting genes: BCAR1 C4BPA CCDC90B CREB3 CREB3L1 GDF9 HAUS2 LMNA PPP1CC RBM48 SLC35E1 TLE1 TP53 TRIM27 UNC119	9 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1
Entrez ID		53826	722
HPRD ID		09456	00403
Ensembl ID		ENSG00000137726	ENSG00000123838
Uniprot IDs		A0A024R3J8 Q9H0Q3	P04003
PDB IDs			2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q
Enriched GO Terms of Interacting Partners?
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