PLXNB1 and NRP2

Number of citations of the paper that reports this interaction (PubMedID 25315821)
12

Data Source:
BioGRID (two hybrid)

		PLXNB1	NRP2
Description		plexin B1	neuropilin 2
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding Signaling Receptor Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Inhibitory Synapse Assembly	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Viral Process Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways		G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse	Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		14 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		5364	8828
HPRD ID		03032	03643
Ensembl ID		ENSG00000164050	ENSG00000118257
Uniprot IDs		O43157	O60462 Q7Z3T9
PDB IDs		2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W	2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8
Enriched GO Terms of Interacting Partners?
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