PLP1 and PTPRN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid, two hybrid)

		PLP1	PTPRN
Description		proteolipid protein 1	protein tyrosine phosphatase receptor type N
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Myelin Sheath Synapse	Cell Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Secretory Granule Transport Vesicle Membrane Neuronal Cell Body Perikaryon Axon Terminus Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding GTPase Binding
	Biological Process	Inflammatory Response Integrin-mediated Signaling Pathway Chemical Synaptic Transmission Axon Ensheathment Glial Cell Differentiation Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Neuron Projection Development Myelination Long-chain Fatty Acid Biosynthetic Process Axon Development	Response To Reactive Oxygen Species Luteinization Cytokine-mediated Signaling Pathway Insulin Secretion Response To Insulin Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS			High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		13 interacting genes: AKT1 BCL2L13 CALR CANX CLN8 CREB3 CREB3L1 GLA ITGAV LMNA MAG MBP PTPRN	13 interacting genes: CAPN2 CLN8 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 UBQLN4
Entrez ID		5354	5798
HPRD ID		02321	03466
Ensembl ID		ENSG00000123560	ENSG00000054356
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	Q16849 Q96IA0
PDB IDs		2XPG	2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?
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