PLD1 and CDC42

Number of citations of the paper that reports this interaction (PubMedID 10747870)
15

Data Source:
HPRD (in vivo, in vitro)

		PLD1	CDC42
Description		phospholipase D1	cell division cycle 42
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Golgi Membrane Storage Vacuole Cell Cytoplasm Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Membrane Golgi Transport Complex Secretory Granule Filopodium Midbody Leading Edge Membrane Cytoplasmic Vesicle Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Mitotic Spindle Schaffer Collateral - CA1 Synapse
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle	Sprouting Angiogenesis Cardiac Conduction System Development Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Cell Migration Protein Ubiquitination Substantia Nigra Development Cell Projection Assembly Actin Cytoskeleton Organization Macrophage Differentiation Positive Regulation Of Cell Growth Cortical Cytoskeleton Organization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein Complex Assembly Positive Regulation Of Cytokinesis Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Interleukin-12-mediated Signaling Pathway Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway Viral RNA Genome Replication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Binding Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA Replication Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Pinocytosis Neuron Fate Determination Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Submandibular Salivary Gland Formation Dendritic Spine Morphogenesis Cellular Response To Interferon-gamma Organelle Transport Along Microtubule Actin Filament Branching Positive Regulation Of Intracellular Protein Transport Regulation Of Modification Of Postsynaptic Structure Modification Of Synaptic Structure Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation	GPVI-mediated activation cascade EGFR downregulation Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		Choline LAX-101	Aminophosphonic Acid-Guanylate Ester Guanosine-5'-Diphosphate
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Red cell distribution width ( 27863252 28957414)	Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	150 interacting genes: A2M ACTR3 AGAP1 AGAP2 AHSG ANXA2 APOH ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF25 ARHGEF6 ARHGEF7 ARRB1 ARRB2 BAIAP2 BCR BIRC2 BNIP2 CASP3 CASP7 CBLL1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDH1 CFHR4 CPN1 CSN2 CSPG4 DEF6 DIAPH2 DIAPH3 DOCK7 DOCK8 DOCK9 EEF1G EIF2AK2 EPHA2 ERCC3 ERG28 ERRFI1 ETFA FGD1 FGD3 FLNA FMN2 FMNL2 FNBP1 GDI1 GRB2 HERC2 IQGAP1 IQGAP2 ITSN1 KAT5 KIAA2026 KTN1 LCK LGALS1 LRIF1 LRP2 MAP2K3 MAP3K10 MAP3K11 MAP3K4 MAP4 MARK4 MCF2 MCF2L MCM3AP METAP2 MT-CO1 MUC12 MYO6 MYO9A NCF2 NEK6 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD3 PARD6A PARD6B PARD6G PCM1 PDE6D PGGT1B PIK3R1 PLD1 PLEKHG2 PRKCA PRKCG PRKCI PRKCZ RAC2 RAP1GDS1 RHOJ RIOK3 RPL22 RPL23 RPS6KB1 S100A9 SH3D19 SRGAP1 SSX2IP ST13 STAU1 SYNE1 TBC1D3F TNK2 TP53 TRAF2 TRIP10 UBC UBR1 UNC119 USP6 VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP ZNF175 ZNF234 ZNF420
Entrez ID		5337	998
HPRD ID		03855	00309
Ensembl ID		ENSG00000075651	ENSG00000070831
Uniprot IDs		Q13393 Q59EA4	A0A024RAE6 P60953
PDB IDs			1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL
Enriched GO Terms of Interacting Partners?
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