SERPINA1 and PRSS2

Number of citations of the paper that reports this interaction (PubMedID 2610933)
2

Data Source:
HPRD (in vitro)

		SERPINA1	PRSS2
Description		serpin family A member 1	serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of Cell Adhesion
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol Recombinant alpha 1-antitrypsin Copper	Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Isopropyl Alcohol Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		Alpha-1-antitrypsin (A1AT) deficiency	Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488 28240269 23696881) Breast size ( 27182965) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Platelet count ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Serum alkaline phosphatase levels ( 31666285) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531)	Blood protein levels ( 29875488) Pancreatitis ( 23143602)
Interacting Genes		28 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE FBLN5 GLP1R GSDMB KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1	7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI
Entrez ID		5265	5645
HPRD ID		02463	03335
Ensembl ID		ENSG00000197249	ENSG00000275896
Uniprot IDs		E9KL23 P01009	A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 7API 8API 9API
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?