PFN1 and APBB1IP

Number of citations of the paper that reports this interaction (PubMedID 15469846)
153

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PFN1	APBB1IP
Description		profilin 1	amyloid beta precursor protein binding family B member 1 interacting protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium T Cell Receptor Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Cadherin Binding Proline-rich Region Binding	Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Signal Transduction Positive Regulation Of Cell Adhesion
Pathways		Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs		7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS			Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory biomarkers ( 22228203) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to angiotensin II receptor blocker therapy ( 22566498) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	10 interacting genes: EVL GAS7 HRAS NDN PFN1 PRPF40A RAB18 RAP1A VASP ZDHHC17
Entrez ID		5216	54518
HPRD ID		01452	16420
Ensembl ID		ENSG00000108518	ENSG00000077420
Uniprot IDs		P07737	Q7Z5R6
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25	2MWN 3ZDL
Enriched GO Terms of Interacting Partners?
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