PFKM and PFKL

Number of citations of the paper that reports this interaction (PubMedID 6444721)
17

Data Source:
HPRD (in vitro)

		PFKM	PFKL
Description		phosphofructokinase, muscle	phosphofructokinase, liver type
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane	Extracellular Region Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Protein Homotetramerization Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Neutrophil Degranulation Negative Regulation Of Insulin Secretion Protein Homotetramerization Canonical Glycolysis
Pathways		Glycolysis	Neutrophil degranulation Glycolysis
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Longevity (90 years and older) ( 25199915) Metabolite levels ( 23823483) Pulse pressure ( 30578418)	Rheumatoid arthritis ( 21505073)
Interacting Genes		15 interacting genes: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 SUMO2 TEAD4 UBTD1	13 interacting genes: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PCNT PFKM PRPF40A TESK1 YWHAQ
Entrez ID		5213	5211
HPRD ID		01988	01385
Ensembl ID		ENSG00000152556	ENSG00000141959
Uniprot IDs		A0A024R0Y5 A0A2R8Y891 P08237	P17858 Q7L2M7
PDB IDs		4OMT
Enriched GO Terms of Interacting Partners?
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