CYB5R2 and CDC23

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CYB5R2	CDC23
Description		cytochrome b5 reductase 2	cell division cycle 23
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Membrane	Intracellular Cell Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding FAD Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Bicarbonate Transport Sterol Biosynthetic Process Oxidation-reduction Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Erythrocytes take up carbon dioxide and release oxygen	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood pressure ( 23972371) Metabolite levels ( 23823483)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		8 interacting genes: CDC23 COIL FFAR2 GOLGA2 PSMC6 TRAF1 TRAF2 TRIP13	45 interacting genes: ANAPC10 APOL1 ATRIP BCAS3 BYSL CBY2 CCDC24 CDC16 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DEPDC1B DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 IHO1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SMARCB1 SMUG1 SOX5 SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		51700	8697
HPRD ID		06435	07221
Ensembl ID		ENSG00000166394	ENSG00000094880
Uniprot IDs		A8K237 Q6BCY4	Q9UJX2
PDB IDs			4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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