GET4 and SOD2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		GET4	SOD2
Description		guided entry of tail-anchored proteins factor 4	superoxide dismutase 2
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol BAT3 Complex	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	Protein Binding Chaperone Binding	Superoxide Dismutase Activity Manganese Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway	Response To Superoxide Age-dependent Response To Reactive Oxygen Species Release Of Cytochrome C From Mitochondria Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Superoxide Metabolic Process Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Removal Of Superoxide Radicals Positive Regulation Of Cell Migration Oxygen Homeostasis Cellular Response To Oxidative Stress Interleukin-12-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Protein Homotetramerization Oxidation-reduction Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Benzylsulfinic Acid 3-Fluorotyrosine
Diseases
GWAS			Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Pulse pressure ( 27841878)
Interacting Genes		21 interacting genes: AKT1 ATP5PD BAG6 CAPNS1 CDKN1A CEP126 EEF1G FLYWCH2 GET3 KAT5 KIFC2 PLK1 PRKAB2 PRKCSH PTMS SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	8 interacting genes: APP CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		51608	6648
HPRD ID		12909	00938
Ensembl ID		ENSG00000239857	ENSG00000112096
Uniprot IDs		Q7L5D6	A0A384NL29 G5E9P6 P04179 Q96AM7 Q9UG59
PDB IDs		6AU8	1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9
Enriched GO Terms of Interacting Partners?
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