UFM1 and DIABLO

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		UFM1	DIABLO
Description		ubiquitin fold modifier 1	diablo IAP-binding mitochondrial protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Brain Development Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Protein Ufmylation Protein K69-linked Ufmylation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Low vWF levels ( 26486471) Schizophrenia ( 30285260)
Interacting Genes		14 interacting genes: ARHGDIA ARHGDIB DIABLO GSK3B RPS6KA6 TSC22D2 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W	23 interacting genes: AGTRAP AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 E2F1 EEF1A1 HTRA2 LTBR MAML2 NR4A1 SBNO1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		51569	56616
HPRD ID		15644	05560
Ensembl ID		ENSG00000120686	ENSG00000184047
Uniprot IDs		P61960	A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs		1WXS 5HKH 5IA7 5IA8 5IAA 5L95 6H77	1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5
Enriched GO Terms of Interacting Partners?
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