ACTL6B and SMARCA2

Number of citations of the paper that reports this interaction (PubMedID 12437990)
8

Data Source:
HPRD (in vivo, in vitro)

		ACTL6B	SMARCA2
Description		actin like 6B	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus SWI/SNF Complex NuA4 Histone Acetyltransferase Complex NBAF Complex	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Structural Constituent Of Cytoskeleton	DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Nervous System Development Dendrite Development Spinal Cord Development Neuron Maturation ATP-dependent Chromatin Remodeling Histone H4 Acetylation Positive Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Hematocrit ( 29403010 28017375) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 29403010 28017375) Red blood cell count ( 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751)
Interacting Genes		12 interacting genes: ANXA7 APP ATM CDKN1A COQ9 CSNK2B CTBP1 GSK3B PLK1 SMARCA2 SMN1 TK1	27 interacting genes: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA ESR1 H3C1 HSPB1 KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 RAP1A SDCBP SIN3B SS18
Entrez ID		51412	6595
HPRD ID		12419	02483
Ensembl ID		ENSG00000077080	ENSG00000080503
Uniprot IDs		O94805	B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1
PDB IDs			2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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