FZR1 and BECN1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FZR1	BECN1
Description		fizzy and cell division cycle 20 related 1	beclin 1
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane	Phagophore Assembly Site Cell Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Extrinsic Component Of Membrane Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol 3-kinase Binding GTPase Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Negative Regulation Of Cell Aging Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Mitotic Metaphase Plate Congression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Protein Localization By The Cvt Pathway Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Cell Division Defense Response To Virus Negative Regulation Of Cell Death Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation	Macroautophagy Ub-specific processing proteases
Drugs			Estradiol
Diseases
GWAS			Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		94 interacting genes: AKT1 AKT1S1 ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC BUB1B C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC20 CDC25A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2A CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PCLAF PDGFRA PLK1 PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 STK11 TEAD2 TERT THRSP TP53 UBE2C UBE2D1 UBE2D3 UBE2K UBE2S	50 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 ITCH KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 NF2 PDGFRA PGK1 RACK1 RAF1 SHD SMAD2 STK11 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1
Entrez ID		51343	8678
HPRD ID		04687	05087
Ensembl ID		ENSG00000105325	ENSG00000126581
Uniprot IDs		Q9UM11	A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4
PDB IDs		4UI9 5L9T 5L9U	2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK
Enriched GO Terms of Interacting Partners?
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