PDCD1 and CD274

Number of citations of the paper that reports this interaction (PubMedID 12719480)
87

Data Source:
HPRD (in vivo)

		PDCD1	CD274
Description		programmed cell death 1	CD274 molecule
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Negative Regulation Of Tolerance Induction Apoptotic Process Humoral Immune Response Multicellular Organism Development T Cell Costimulation Negative Regulation Of Apoptotic Process Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process	Adaptive Immune Response Positive Regulation Of Tolerance Induction To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Response To Cytokine Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Toxin Transport Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Interleukin-10 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		PD-1 signaling	PD-1 signaling
Drugs		CT-011 Nivolumab Pembrolizumab	Atezolizumab Durvalumab Avelumab
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919)	Blood protein levels ( 30072576)
Interacting Genes		2 interacting genes: CD274 PDCD1LG2	2 interacting genes: CD80 PDCD1
Entrez ID		5133	29126
HPRD ID		02590	05655
Ensembl ID		ENSG00000188389	ENSG00000120217
Uniprot IDs		A0A0M3M0G7 Q15116	Q0GN75 Q9NZQ7
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6UMT 6UMU 6UMV	3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6R3K 6RPG
Enriched GO Terms of Interacting Partners?
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