PCSK2 and SCG5

Number of citations of the paper that reports this interaction (PubMedID 11439082)
41

Data Source:
HPRD (in vitro, in vivo)

		PCSK2	SCG5
Description		proprotein convertase subtilisin/kexin type 2	secretogranin V
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Trans-Golgi Network Membrane Transport Vesicle Secretory Granule Integral Component Of Golgi Membrane Dendrite Perikaryon Intracellular Membrane-bounded Organelle	Extracellular Region Nucleus Secretory Granule
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein-containing Complex Binding	Enzyme Inhibitor Activity Protein Binding GTP Binding Enzyme Regulator Activity Unfolded Protein Binding
	Biological Process	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing	Intracellular Protein Transport Neuropeptide Signaling Pathway Peptide Hormone Processing Negative Regulation Of Catalytic Activity Regulation Of Hormone Secretion
Pathways		Insulin processing
Drugs		Insulin Human Insulin Pork
Diseases
GWAS		Biochemical measures ( 19260141) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)	Chin dimples ( 27182965) Colorectal cancer ( 25990418 30529582 21761138 24737748) Obesity-related traits ( 23251661)
Interacting Genes		3 interacting genes: IAPP PMCH SCG5	5 interacting genes: KHDRBS1 NR1H2 PCSK2 UBQLN1 UBQLN4
Entrez ID		5126	6447
HPRD ID		01202	01410
Ensembl ID		ENSG00000125851	ENSG00000166922
Uniprot IDs		P16519	A0A024R9I1 P05408
PDB IDs
Enriched GO Terms of Interacting Partners?
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